Cisplatin mechanism of hearing loss
WebJun 21, 2024 · In this trial, the addition of delayed sodium thiosulfate to cisplatin led to a 48% lower risk of hearing loss. Hearing loss of grade 1 or higher occurred in 63% of the children who did... WebAug 25, 2024 · This hypothesis was supported by the late increase in hearing loss after a single dose of cisplatin, emphasizing the role of the supporting cells in the cochlear …
Cisplatin mechanism of hearing loss
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WebFeb 9, 2016 · INTRODUCTION. Ototoxicity, manifesting as hearing loss, tinnitus, and/or vertigo, is a well-established toxicity associated with a subgroup of antineoplastic therapies that include platinum chemotherapy and radiation or surgery involving the ear and auditory nerve. Supportive care agents, such as aminoglycoside antibiotics and loop diuretics ... WebJun 21, 2024 · In this trial, the addition of delayed sodium thiosulfate to cisplatin led to a 48% lower risk of hearing loss. Hearing loss of grade 1 or higher occurred in 63% of the children who did...
Web20 hours ago · The drug, which is Fennec's sole product, is intended to prevent hearing loss in pediatric cancer patients treated with cisplatin chemotherapy. WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in cisplatin-induced ototoxicity in vitro and in vivo. Sprague–Dawley rats (SD, 8 …
WebMay 2, 2014 · Cisplatin-induced hearing loss is favoured either by preexisting afflictions like hypoalbuminemia, anaemia, renal failure, and noise-induced hearing loss or by risk … WebSep 20, 2024 · The primary outcome was hearing loss according to American Speech-Language-Hearing Association (ASHA) criteria, assessed at baseline and 4-weeks after …
WebMar 26, 2024 · Acquired hearing loss may have multiple causes, but one of the common causes in childhood follows treatment for childhood cancer with cisplatin. For a sound to be perceived, it has to travel through the …
WebMay 19, 2016 · Dr. Chang's clinical practice is based at the Lucile Packard Children's Hospital, and is focused on Pediatric Otology. He has specific … hungarian outletWebJan 26, 2024 · Results from a new study may explain why many patients treated with the chemotherapy drug cisplatin develop lasting hearing loss. Researchers found that, in both mice and humans, cisplatin can be … hungarian ottoman rebelsWebApr 6, 2016 · Significance statement: Cisplatin is a widely used chemotherapeutic agent for the treatment of solid tumors. Its use results in significant and permanent hearing loss, for which no US Food and Drug Administration-approved treatment is currently available. hungarian packWebSep 1, 2024 · Cisplatin for injection can cause ototoxicity, which is cumulative and may be severe. Consider audiometric and vestibular function monitoring. Ototoxicity is manifested by tinnitus, hearing loss in the high frequency range (4,000 to 8,000 Hz) and/or decreased ability to hear normal conversational tones. hungarian p63 for saleWebJul 2, 2024 · The ABR threshold shift in animals treated with caffeine + R -PIA + cisplatin was 1.0 ± 1.0, 3.3 ± 1.7 and 4.2 ± 0.8 at 8, 16 and 32 kHz, respectively. These findings suggest that single oral ... hungarian pa 63 magazineWeb2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the … hungarian overcoatWebMar 1, 2024 · Although the mechanisms behind cisplatin-associated ototoxicity have not been completely explained, it may mainly involve ROS accumulation in the inner ear, causing a significant increase in lipid peroxidation, consumption of intracochlear antioxidants, and calcium influx, subsequently inducing apoptosis5. hungarian palaces