Cyp46a1 protein
WebJan 1, 2024 · Consistent with HMGCR, CYP46A1 protein level was up-regulated in response to Aβ treatment. Based on our findings, we can suggest that increased expression of CYP46A1 level can be a regulatory positive feedback to keep neurons active in order to inhibit cholesterol accumulation in case of increased levels of HMGCR protein and … WebMar 6, 2024 · Increased bile acid levels in the brain activated FXR signaling, which downregulated the expression of brain Cyp46A1 (catalyzes the synthesis of 24(S)-hydroxycholesterol) in mice (Fig. 7) . Open in a separate window ... Takeda G protein receptor 5 (TGR5) is a cell-surface G protein coupled receptor, ...
Cyp46a1 protein
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• Human CYP46A1 genome location and CYP46A1 gene details page in the UCSC Genome Browser. • UniProt entry on Cholesterol-24 hydroxylase • HMDB Database entry • RCSB Protein Data Bank Entry WebJun 2, 2024 · The protein levels of (B) HMGCR, (D) ApoE and (F) CYP46A1 were measured by Western blots. Shown are representative blots for each protein with β-actin used as a loading control.
WebCYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer's disease CYP46A1 inhibition, brain cholesterol accumulation and … WebCyp46A1 mRNA and CYP46A1 protein levels were also decreased in the striatum of the R6/2 Huntington’s disease mouse model and in SThdhQ111 cell lines. In vivo, in a wild-type context, knocking down CYP46A1 expression in the striatum, via an adeno-associated virus-mediated delivery of selective shCYP46A1, reproduced the Huntington’s disease ...
WebAnti-CYP46A1抗体. Product Properties. Cat Code Product Name Clonality Cross reactivity Application MW(kDa). 508573 Anti-CYP46A1 Rabbit pAb Rabbit pAb Human,Mouse,Rat WB 57kDa. Sensitivity . Anti-CYP46A1抗体Immunogen Recombinant protein of human CYP46A1. Host Rabbit. Clone Number . Anti-CYP46A1抗体Antibody type Polyclonal … WebCholesterol 24-hydroxylase (CH24H or CYP46A1) is a brain-specific cytochrome P450 enzyme that metabolizes cholesterol into 24S-hydroxycholesterol (24HC) for regulating brain cholesterol homeostasis.
WebJan 1, 2024 · The present study demonstrates the diverse potential effects of CYP46A1 deficiency on brain functions and identifies important proteins that could be affected by this deficiency Increased expression of CYP46A1 in the striatum decreased neuronal atrophy in a Huntington's disease model.
WebApr 1, 2024 · Reduced Cyp46A1 level at terminal stages of prion disease in prion-infected mice and sCJD patients. To assess a potential role of Cyp46A1 in prion disease, we analyzed its protein levels at the terminal stage of prion disease after intracerebral (i.c.) inoculation of three well established scrapie strains (RML, 22L and ME7) into FVB mice. tokyo rose actress massenWebJul 16, 2013 · The CYP46A1 protein in the brain was located to neuronal cells. It is evident that there are very specific requirements for expression of this protein in different cells. Under normal conditions CYP46A1 protein is almost exclusively expressed in neuronal cells in the brain and in the eye. It seems likely that there a number of restrictions ... people vs adlawanWebMar 22, 2024 · When Cyp46A1 was overexpressed in NIH3T3 cells, intrinsic oxysterols increased in the order 24S-HC > 25-HC > 27-HC. We investigated the mechanism regulating the production of endogenous oxysterols in NIH3T3 cells by Cyp46A1 and found that the mRNA, relative protein levels and enzymatic activity of Cyp46A1, and the amounts of … tokyo roadshowWebThis endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. ... CYP46A1 open_in_new. Ensembl ID . ENST00000261835 ... tokyo rm english lyricsWebMar 21, 2024 · CYP46A1 (Cytochrome P450 Family 46 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP46A1 include Alzheimer Disease, Familial, 1 and Cerebrotendinous Xanthomatosis . Among its related pathways are Oxidation by … FASN (Fatty Acid Synthase) is a Protein Coding gene. Diseases associated with … CYP1A2 (Cytochrome P450 Family 1 Subfamily A Member 2) is a Protein … ACE (Angiotensin I Converting Enzyme) is a Protein Coding gene. Diseases … SLC7A5 (Solute Carrier Family 7 Member 5) is a Protein Coding gene. Diseases … NOX4 (NADPH Oxidase 4) is a Protein Coding gene. Diseases associated with … FDFT1 (Farnesyl-Diphosphate Farnesyltransferase 1) is a Protein … CYP1B1 (Cytochrome P450 Family 1 Subfamily B Member 1) is a Protein … ACHE (Acetylcholinesterase (Cartwright Blood Group)) is a Protein Coding gene. … PLAU (Plasminogen Activator, Urokinase) is a Protein Coding gene. Diseases … tokyo rig for walleyeWebCYP46A1 Protein Overview. Lund et al. (1999) used expression cloning to isolate cDNAs that encode murine and human cholesterol 24-hydroxylases. DNA sequence … tokyo rumando orpheeWebCYP46A1 is part of cluster 3 Plasmacytoid DCs - Unknown function with confidence i ... Protein tyrosine phosphatase receptor type S: 0.9430: 3: UGCG: UDP-glucose ceramide glucosyltransferase: 0.9430: 3: TPM2: Tropomyosin 2: 0.9346: 3: SLC35F3: Solute carrier family 35 member F3: 0.9279: 3: CUX2: Cut like homeobox 2: tokyo rush hour