WebOnly since the 1990s has a series of studies demonstrated that PHT users have a twofold to fourfold increased risk of venous thrombosis, and that PHT, regardless of duration of use, increases thrombosis risk. As with HC, studies have shown that the risk of VTE is highest during the first year of use. Pathophysiology Webwith PE was pneumonia, with its frequency being 2-fold higher in patients with unprovoked PE than in those with provoked PE (Table 3). DISCUSSION We aimed to investigate the risk factors associated with provoked PE, including the alteration of the factors as-sociated with coagulation. We found infection and pro-
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